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Sarafotoxin S6b
Name
Sarafotoxin S6b
Molecular structural formula
Purity
≥95%
CAS Number
120972-53-4
Formula
C105H156N28O34S5
MW
2514.9
Target
Endothelin Receptor
Sequence
Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Shortening
CSCKDMTDKECLYFCHQDVIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
References
[1]. P S Devadason et al. Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery. Br J Pharmacol. 1997 May;121(2):253-63.
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Product details
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Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the Ki values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively.