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Synthesis of unnatural amino acids and other blocks
Glucagon
Name
Glucagon
Molecular structural formula
Purity
≥98%
Formula
C153H225N43O49S
MW
3482.7
Target
Amylin Receptor
Sequence
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr
Sequence Shortening
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
InChIKey
MASNOZXLGMXCHN-ZLPAWPGGSA-N
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Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia. Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose. Glucagon was granted FDA approval on 14 November 1960.