Name
BCLX (L) -HLA A2(Peptide Sequence: YLNDHLEPWI)
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Molecular structural formula
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Normal/Tumor
ubiquitous (low level)(RNA)
ubiquitous (low level)(RNA)
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Peptide Sequence
YLNDHLEPWI
YLNDHLEPWI
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Lymphocyte Stimulation
peptide
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NCBI Gene SummaryNCBI
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
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GeneCards Summary
BCL2L1 (BCL2 Like 1) is a Protein Coding gene. Diseases associated with BCL2L1 include Absolute Glaucoma and B-Cell Lymphoma. Among its related pathways are MAPK family signaling cascades and Nuclear events mediated by NFE2L2. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2.
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UniProtKB SwissProt Summary
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
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References
[1].Sørensen RB1, Hadrup SR, Køllgaard T, Svane IM, thor Straten P, Andersen MH. Efficient tumor cell lysis mediated by a Bcl-X(L) specific T cell clone isolated from a breast cancer patient. Cancer Immunol Immunother. 2007 Apr, 56(4):527-33. (PMID: 16850344).
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