Bradykinin CAS:58-82-2 Sequence:RPPGFSPFR Motifbiotech

Bradykinin is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions.

Name Bradykinin	Molecular structural formula
Purity ≥95%
CAS Number 58-82-2
Formula C50H73N15O11
MW 1060.22
Target Bradykinin Receptor; Endogenous Metabolite; Ser/Thr Protease.
Sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Sequence Shortening RPPGFSPFR
InChIKey QXZGBUJJYSLZLT-FDISYFBBSA-N
Solubility in water ≥ 100 mg/mL
References [1]. Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8. [2]. Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32(4):1709-14. [3]. Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37(4):1592-606. [4]. Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62. [5]. Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50.