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Home / Peptide products / B (44 species) / Bradykinin / Bradykinin
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Bradykinin
Name
Bradykinin
Molecular structural formula
Purity
≥95%
CAS Number
58-82-2
Formula
C50H73N15O11
MW
1060.22
Target
Bradykinin Receptor; Endogenous Metabolite; Ser/Thr Protease.
Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Sequence Shortening
RPPGFSPFR
InChIKey
QXZGBUJJYSLZLT-FDISYFBBSA-N
Solubility in water
≥ 100 mg/mL
References
[1]. Hornig B, et al. Role of bradykinin in mediating vascular effects of angiotensin-converting enzyme inhibitors inhumans. Circulation. 1997 Mar 4;95(5):1115-8. [2]. Wang G, et al. Bradykinin stimulates IL-6 production and cell invasion in colorectal cancer cells. Oncol Rep. 2014 Oct;32(4):1709-14. [3]. Dong R, et al. Exogenous Bradykinin Inhibits Tissue Factor Induction and Deep Vein Thrombosis via Activating the eNOS/Phosphoinositide 3-Kinase/Akt Signaling Pathway. Cell Physiol Biochem. 2015;37(4):1592-606. [4]. Uchida S, et al. Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats. Auton Neurosci. 2015 Dec;193:57-62. [5]. Liu LT, et al. Effect of vascular bradykinin on pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. Eur Rev Med Pharmacol Sci. 2015;19(14):2646-50.
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Bradykinin is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions.