Polypeptide Modification

Peptides are active substances that perform various functions in living organisms and have significant structural advantages. On the basis of not affecting the original functional peptide fragments, a new functional peptide sequence can be introduced into one or both ends of the polypeptide through solid-phase synthesis or biosynthesis to obtain a multifunctional fusion peptide. Polypeptide modification can change the physicochemical properties of peptide compounds and optimize their effective use in vivo.

Peptide modification has a wide range of applications, including but not limited to medicine, cosmetics, food and agriculture. In the medical field, peptide modification can be used for the development and optimization of drugs, such as targeted drugs, therapeutic antibodies, etc. In the field of cosmetics, peptide modification is mainly used to improve skin conditions, such as repairing skin barrier, antibacterial and anti-inflammatory, brightening hydration and so on. In addition, peptide modifications can also be used in food and agriculture, such as improving food taste and nutritional value, and increasing plant stress resistance.

Polypeptide modification techniques are mainly divided into liquid phase method and solid phase method. The liquid-phase method refers to the synthesis and modification of polypeptides in the solution state, while the solid-phase method is to connect polypeptide chains on the solid phase matrix and modify them. Common peptide modifications include C-terminal modification, N-terminal modification, intermediate residue modification and cyclization modification. These modifications can change the physical and chemical properties of peptides, such as solubility, stability, biological activity, etc., to optimize their effective use in vivo.

Motif has advanced peptide synthesis capabilities and offers more than 300 modification types to meet your needs in different areas of research. Peptide modification technologies are diverse and can be customized and optimized according to different customer needs.

At present, MOTIF has successfully synthesized sequences as follows:

Phosphorylated modification: (1) biotin (P) - * * - * - S - S (P) - P (P) - P * * * - S - S (P) - * S - acid (left)

(2) fluorescence modification: Gln - Val - * * * * * - Cys - Met - His - * * * * * - Leu - Glu - Ile - * * * * * - Glu - Arg - Val - Glu - * * * * * - Leu - Ser - Asp - Cy5 (center)

(3) FMK modification: Z-****-FMK (right picture)