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µ-Conotoxin-CnIIIC
Name
µ-Conotoxin-CnIIIC
Molecular structural formula
Purity
≥95%
CAS Number
936616-33-0
Formula
C92H139N35O28S6
MW
2375.70
Target
Sodium Channel
Sequence
{Glp}-Gly-Cys-Cys-Asn-Gly-Pro-Lys-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22)
Sequence Shortening
{Glp}-GCCNGPKGCSSKWCRDHARCC-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22)
References
[1]. Markgraf R, et al. Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br J Pharmacol. 2012 Oct;167(3):576-86. [2]. Del Río-Sancho S, et al. Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant properties. Int J Pharm. 2017 Feb 25;518(1-2):59-65.
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Conotoxin is a sequential, synthetic biological product that mimics conotoxin, which has a very strong muscle relaxant effect, which can make users feel the immediate anti-wrinkle effect, and is widely used in anti-wrinkle products. Conotoxin is a highly folded peptide with strong penetration, high stability, and a targeted relaxation effect on the muscles. By blocking the conduction of nerve-muscular electrical currents, wrinkles are instantly lightened, and the skin is rejuvenated and looks younger.