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Somatostatin acetate
Name
Somatostatin acetate
Molecular structural formula
Purity
≥98%
CAS Number
54472-66-1
Formula
C78H108N18O21S2
MW
1697.9
Sequence
H-Ala-Gly-Cys(1)-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys(1)-OH.CH3CO2H
Sequence Shortening
AGCKNFFWKTFTSC
InChIKey
GFYNCDIZASLOMM-HMAILDBGSA-N
References
[1]Antiproliferative effect of octretide on gastric cancer cells m ediated by inhibition of telom erase.GAO S,YU BP,LI Y,et al.World Journal of Gastroenterology.2003 [2]Antiproliferative activ-ity induced by the som atostatin analogue,TT-232on hum an pan-creatic cancer cells.LEE JU,H OSOTANI R,W ADA M,et al.European Journal of Cancer.2002 [3]Som atostatin analog RC-160inhibits growth of CFPAC-1hum an pancreatic cancer cells in vitro and intracellular production of cyclic adenosine m onophosphate.QIN Y,ERTL T,GROOT K,et al.International Journal of Cancer.1995 [4]Inhibition of som atostatin analog Octreotide on hum an gastric cell M KN45in vitro.W ANG XB,W ANG X,ZANG NZ.Shijie H uaren Xiaohua Zazhi.2002 [5]Inhibition effects of som ato-statin on hepatocellular carcinom a in vitro and in vivo.H UA YP,LIANG LJ,H UANG JF.China Journal of M odern M edicine.2003
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Somatostatin Acetate (also known as Growth Hormone Inhibitory Hormone (GHIH) or Growth Hormone Release Inhibitory Factor (SRIF)) or Growth Hormone Release Inhibitory Hormone is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation through interaction with G proteins. Couples somatostatin receptors and inhibits the release of many secondary hormones. Somatostatin regulates insulin and glucagon. Somatostatin acetate inhibits and stimulates the thyroid gland and secretes insulin and glucagon. Secretion can be inhibited by a test meal and five pentapeptide gastrin to stimulate gastric acid, pepsin and inhibit the release of gastrin.