Acetyl Hexapeptide-49 relieves neuropathic inflammatory responses by inhibiting the activity of PAR-2 and reduces the release of inflammatory mediators CGRP, IL6 and IL8 by skin cells, reducing persistent pain, itching and other discomforts in sensitive skin. At the same time, acetyl hexapeptide-49 can also repair damaged skin, rebuild barrier function, for particularly dry and sensitive skin, acetyl hexapeptide-49 can increase skin moisture content, improve skin peeling, roughness and suppleness.