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Home / Peptide products / C (134 species) / Cortistatin / Cortistatin 14 (mouse, rat)
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Cortistatin 14 (mouse, rat)
Name
Cortistatin 14 (mouse, rat)
Molecular structural formula
Purity
≥95%
CAS Number
186901-48-4
Formula
C81H113N19O19S2
MW
1721.05
Target
Somatostatin Receptor
Sequence
Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys(Disulfide bridge:Cys2-Cys13)
Sequence Shortening
PCKNFFWKTFSSCK-NH2 (Disulfide bridge: Cys2-Cys13)
Solubility in water
100mg/mL
References
[1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5. [2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6. [3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60. [4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.
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Cortistatin 14 (mouse, rat), a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin 14 (mouse, rat) shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties.