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PAR-1-selective peptide
Name
PAR-1-selective peptide
Molecular structural formula
Purity
≥95%
CAS Number
141136-85-8
Formula
C35H58N10O9
MW
762.91
Target
Protease Activated Receptor (PAR)
Sequence
Thr-Phe-Leu-Leu-Arg-Asn
Sequence Shortening
TFLLRN
InChIKey
HIKQWJFKUWYBNJ-GSAYKZDLSA-N
References
[1]. Stefanie Gödecke, et al. Thrombin-induced ATP release from human umbilical vein endothelial cells. Am J Physiol Cell Physiol. 2012 Mar 15;302(6):C915-23. [2]. Heider I, et al. PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism. Oncol Res. 2004;14(10):475-482.
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Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor.