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TfR Targeting Peptide、TfR-T12
Name
TfR Targeting Peptide、TfR-T12
Molecular structural formula
Purity
95%
CAS Number
344618-30-0
Formula
C71H99N19O15S1
MW
1490.73
Target
Transferrin Receptor
Sequence
Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro-OH
Sequence Shortening
THRPPMWSPVWP
InChIKey
DZRUHTLPVFYMDV-YMGLLDFPSA-N
References
[1]. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41. [2]. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487.
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TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.The 12-mer peptide sequence is a transferrin receptor (TfR) targeting peptide. It binds to TfR and is internalized via endocytosis into TfR-expressing cells. TfR targeting peptide is a potential carrier for transportation of small molecules across the blood-brain barrier to the brain, or into malignant tissues.