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Carbetocin
Name
Carbetocin
Molecular structural formula
Purity
≥98%
CAS Number
37025-55-1
Formula
C45H69N11O12S
MW
988.2
Target
Oxytocin Receptor
Sequence
Unk-Tyr(Me) - Ile - GIn -Asn- Cys- Pro -Leu- Gly一NH2
Sequence Shortening
Unk-Y(Me)-IQNCPLG-NH2
InChIKey
NSTRIRCPWQHTIA-DTRKZRJBSA-N
Solubility in DMSO
≥ 31 mg/mL
Solubility in water
≥ 33.33 mg/mL
References
[1]. Stella Chaviaras, et al. Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Psychopharmacology (Berl). 2010 May;210(1):35-43. [2]. Gerald Gimpl, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510(1-2):9-16. [3]. David Feifel, et al. The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating. Eur Neuropsychopharmacol. 2012 May;22(5):374-8.
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Carbetocin is a long-acting synthetic agonist analogue of human oxytocin, with antihemorrhagic and uterotonic activities. Upon administration, carbetocin targets, binds to and activates peripheral oxytocin receptors that are present on the smooth musculature of the uterus. This causes uterus contractions and prevents excessive bleeding after childbirth, particularly following Cesarean section, and may be used to decrease blood loss during hysteroscopic myomectomy.