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Home / Peptide products / C (134 species) / Calcitonin / Calcitonin Gene Related Peptide II, rat
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Calcitonin Gene Related Peptide II, rat
Name
Calcitonin Gene Related Peptide II, rat
Molecular structural formula
Purity
≥95%
CAS Number
99889-63-1
Formula
C163H265N51O50S2
MW
3803.39
Target
CGRP Receptor
Sequence
Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala- Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2(Disulfide bridge Cys2-Cys7)
Sequence Shortening
SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSKAF-NH2 (Disulfide bridge: Cys2-Cys7)
References
[1]. D Wu, et al. Development and potential of non-peptide antagonists for calcitonin-gene-related peptide (CGRP) receptors: evidence for CGRP receptor heterogeneity. Biochem Soc Trans. 2002 Aug;30(4):468-73. [2]. F M Wisskirchen, et al. CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification. Br J Pharmacol. 2000 May;130(2):464-70. [3]. K Husmann, et al. Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol. 2000 Apr 25;162(1-2):35-43. [4]. M Sheykhzade, et al. Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol. 1998 Apr;123(7):1464-70. [5]. Kenneth A Petersen, et al. Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat. Br J Pharmacol. 2004 Nov;143(6):697-704.
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Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases