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Alarelin
Name
Alarelin
Molecular structural formula
Purity
≥98%
CAS Number
79561-22-1
Formula
C60H86N16O16
MW
1287.42
Target
GnRH Receptor
Sequence
Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt
Sequence Shortening
{Pyr}-HWSYALRP-NHEt
InChIKey
QLGKMLRGKPKGKI-QWQCQAQZSA-N
Solubility in DMSO
62.5 mg/mL
Solubility in water
100 mg/mL
References
[1]. Chen L, et al. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats. World J Gastroenterol. 2004 Jun 15;10(12):1780-4. [2]. Chen L, et al. Distribution, cloning and sequencing of GnRH, its receptor, and effects of gastric acid secretion of GnRH analogue in gastric parietal cells of rats. Life Sci. 2005 Feb 4;76(12):1351-65.
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Alaurelin (gonadotrophin releasing hormoneanalogue (GnRH-A), also known as protamide, is a nine-peptide analogue of synthetic gonadotropin-releasing hormone (GnRH), which is 15 times more potent than the parent body. At the initial stage of medication, it can stimulate the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), causing a transient increase in ovarian-derived steroid hormones; Repeated medication can inhibit the release of LH and FSH from the pituitary gland, reduce the level of estradiol in the blood, achieve the effect of drug ovaries, and regulate the expression of related oncogenes ras, neu and myc of endometrial cancer. Clinically, it is mainly used to induce ovulation, treat infertility caused by abnormal ovarian function, endometriosis and uterine fibroids, and improve pregnancy rate.