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Synthesis of unnatural amino acids and other blocks
Amylin, rat
Name
Amylin, rat
Molecular structural formula
Purity
≥95%
CAS Number
124447-81-0
Formula
C167H272N52O53S2
MW
3920.44
Target
Amylin Receptor
Sequence
Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence Shortening
KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY-NH2 (Disulfide bridge: Cys2-Cys7)
InChIKey
AGQDOUOEJSDDQH-BJQYWQRQSA-N
Solubility in DMSO
50 mg/mL
Solubility in water
100 mg/mL
References
[1]. Bower RL, et al. Amylin structure-function relationships and receptor pharmacology: implications for Amylin mimetic drug development. Br J Pharmacol. 2016 Jun;173(12):1883-98.
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Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.