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Teplow's Amyloid β-Protein (1-42) (scrambled II)
Name
Teplow's Amyloid β-Protein (1-42) (scrambled II)
Molecular structural formula
Purity
95%
CAS Number
1987844-92-7
Formula
C203H311N55O60S1
MW
4514.04
Target
Amyloid-β
Sequence
Tyr-His-Ala-Gly-Val-Asp-Lys-Glu-Val-Val-Phe-Asp-Glu-Gly-Ala-Gly-Ala-Glu-His-Gly-Leu-Ala-Gln-Lys-Ile-Val-Arg-Gly-Phe-Gly-Val-Ser-Asp-Val-Ser-Met-Ile-His-Ile-Asn-Leu-Phe
Sequence Shortening
YHAGVDKEVVFDEGAGAEHGLAQKIVRGFGVSDVSMIHINLF
References
[1].Design, Characterization, and Use of a Novel Amyloid β-Protein Control for Assembly, Neurotoxicity, and Gene Expression Studies.
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This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.