PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat) CAS:143748-18-9 Motif Biotech

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Home / Peptide products / P (129 species) / PACAP / PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat)

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PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat)

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Name PACAP-38 (6-38) (human, chicken, mouse, ovine, porcine, rat)	Molecular structural formula
Purity ≥95%
CAS Number 143748-18-9
Formula C182H300N56O45S
MW 4024.8
Target PACAP Receptor
Sequence Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
Sequence Shortening FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
References [1]. Gourlet P, et al. Fragments of pituitary adenylate cyclase activating polypeptide discriminate between type I and II recombinant receptors. Eur J Pharmacol. 1995 Dec 4;287(1):7-11. [2]. Yang TT, et al. Changes of dopamine content and cell proliferation by dexamethsone via pituitary adenylate cyclase-activating polypeptide in PC12 cell. Neurosci Lett. 2007 Oct 9;426(1):45-8. [3]. Girard BM, et al. Intravesical PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in NGF-OE Mice. J Mol Neurosci. 2016 Jun;59(2):290-9.

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PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.