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Home / Peptide products / Human body system / Domain / Inhibitor of Thrombospondin (TSP-1) (TFA)
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Inhibitor of Thrombospondin (TSP-1) (TFA)
Name
Inhibitor of Thrombospondin (TSP-1) (TFA)
Molecular structural formula
Purity
95%
CAS Number
162559-45-7
Formula
C21H41N5O6
MW
459.58
Target
TGF-beta/Smad
Sequence
Leu-Ser-Lys-Leu
Sequence Shortening
LSKL
InChIKey
KEJKLBKXNJSXOW-QAETUUGQSA-N
Solubility in water
14.29 mg/mL
References
[1].Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model. [2]. In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1. [3].LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-β1 signaling activity following subarachnoid hemorrhage in rats.
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LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier.