CRO
CDMO
CMO
Testing services
Scientific Customized Peptides
General linear peptide synthesis
Long peptide synthesis
Cyclic peptide synthesis (staple peptide)
Cyclic peptide synthesis (disulfide ring formation)
Stable isotope labeling peptide synthesis
Glycopeptides
Polypeptide modification
Peptide library synthesis
View all
Linker Synthesis Service
ADC Linker Synthesis Service
PDC Drug Synthesis Services
View all
FTE Services
PEPTIDE FTE
View all
Learn more
Popular peptides
Beauty peptides
Drug peptide intermediates and impurities
Cancer antigenic peptide
Catalog peptides
Linker
Synthesis of unnatural amino acids and other blocks
Human body system
HA 12CA5 Epitope
Cys-Angiopep-2
[Ala9]Autocamtide2
(Val²)-Amyloid β-Protein (1-42)
N-Acetyl lysyltyrosylcysteine amide
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide
MPG
Ganirelix
View all
Bioanalytical drug development
Ac-RADARADARADARADAYKKIIKKLRGDSP-NH2
Boc-VLGR-pNA
DADE-S(OGlcNAc)-L
c(His-Phe)
Suc-GP-AMC
Cell Adhesive Peptide [RGDC]
HSV-1-amide UL 26 Open Reading Frame (242-255)
RRAAEELDSRAG-S(OGlcNAc)-PQL
View all
Nano Peptide
DArg9
RADA16
Hel 13-5
LIVAGD
Cadherin Peptide , avian
LF-NH2
FITC-LC-TAT (47-57)
LF
View all
Learn more
Home / Peptide products / Linker Intermediate / Advanced Linker Intermediate / Fmoc-Val-Cit-PABC-PNP
Filters
Popular peptides
Human body system
Tripeptide Peptide Tag Domain Antagonist peptides Blocker Peptides Antimicrobial peptides Amyloid peptides Inhibitor peptides Targeted Peptide Agonist Peptide
Bioanalytical drug development
RGD Peptides Glycopeptides Dipeptide Cyclodipeptide Substrate Peptide
Nano Peptide
Self-assembling peptides Cell-penetrating Peptides
Beauty peptides
Anti-aging
Anti-inflammatory
Repair
Moisturizing
Whitening
Body care
Drug peptide intermediates and impurities
Neoplasm
Diabetes mellitus
Cardiovascular
Reproductive
Anti-infection
Osteoporosis
Other
Cancer antigenic peptide
Mutation
Differentiation
Overexpressed
Tumor-specific
Catalog peptides
Linker
ADC Linker
Peptide Linker
PDC Linker
RDC linker
PROTAC linker
Reactive Linker
Alkyne Reactive Linker Amine Reactive Linker Azide Reactive Linker Click Reactive Linker Thiol Reactive Linker
Linker Intermediate
Advanced Linker Intermediate
Synthesis of unnatural amino acids and other blocks
Fmoc protects unnatural amino acids
Fmoc-Val-Cit-PABC-PNP
Name
Fmoc-Val-Cit-PABC-PNP
Molecular structural formula
Purity
≥95%
CAS Number
863971-53-3
MW
766.80
Target
ADC Linker
InChIKey
USMYACISHVPTHK-PXLJZGITSA-N
Solubility in DMSO
≥ 40 mg/mL
References
[1]. Dubowchik GM, et al. Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug Chem. 2002 Jul-Aug;13(4):855-69. [2]. Yoneda Y, et al. A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1632-6. [3]. Dorywalska M, et al. Effect of attachment site on stability of cleavable antibody drug conjugates. Bioconjug Chem. 2015 Apr 15;26(4):650-9.
* All products on our website are for scientific research and cannot be used in human body
Product details
Data download

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers.