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Home / Peptide products / Reactive Linker / Click Reactive Linker / DBCO-acid
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DBCO-acid
Name
DBCO-acid
Molecular structural formula
Purity
≥95%
CAS Number
1353016-70-2
Formula
C19H15NO3
MW
305.33
Target
ADC Linker
InChIKey
NDLOVDOICXITOK-UHFFFAOYSA-N
Solubility in DMSO
100 mg/mL
References
[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.
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Product details
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DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1]. DBCO-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.