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Home / Peptide products / I (62 species) / IGF / IGF-I (1-3)
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IGF-I (1-3)
Name
IGF-I (1-3)
Molecular structural formula
Purity
≥95%
CAS Number
32302-76-4
Formula
C12H19N3O6
MW
301.30
Sequence
Gly-Pro-Glu
Solubility in DMSO
66.67 mg/mL
References
[1]. Sara VR, et al. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989 Dec 15;165(2):766-71. [2]. Aguado-Llera D, et al. Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex. Neuroreport. 2004 Aug 26;15(12):1979-82.
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Product details
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IGF-I (1-3) is a neuroactive peptide with a potent action on acetylcholine release. IGF-I (1-3)u is the N-terminal tripeptide of insulin-like growth factor-I. IGF-I (1-3) inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection