C-Type Natriuretic Peptide (1-22), human CAS：127869-51-6 Motif Biotech

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Home / Peptide products / N (115 species) / Natriuretic peptide / C-Type Natriuretic Peptide (1-22), human

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C-Type Natriuretic Peptide (1-22), human

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Name C-Type Natriuretic Peptide (1-22), human	Molecular structural formula
Purity ≥95%
CAS Number 127869-51-6
Formula C93H157N27O28S3
MW 2197.64
Target others
Sequence Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys(Disulfide bridge:Cys6-Cys22)
Sequence Shortening GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22)
InChIKey UHSBKBYWHCBDCJ-DYGWFTAGSA-N
References [1]. Morozumi N, et al. ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. PLoS One. 2019 Feb 22;14(2):e0212680. [2]. Buckley MG, et al. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond). 2000 Nov;99(5):467-72. [3]. Mazarati AM, et al. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Life Sci. 1993;52(3):PL19-24

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C-Type Natriuretic Peptide (CNP) (1-22), human, a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor.