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Home / Peptide products / Human body system / Agonist Peptide / Hemokinin 1 (human)
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Hemokinin 1 (human)
Name
Hemokinin 1 (human)
Molecular structural formula
Purity
95%
CAS Number
491851-53-7
Formula
C54H84N14O14S1
MW
1185.4
Target
Neurokinin Receptor
Sequence
Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening
TGKASQFFGLM-NH2
InChIKey
NYBLUYYRUFKGTB-XJCFQSCISA-N
Solubility in water
≥ 50 mg/mL
References
[1].Cai-Yun Fu, et al. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS One. [2].Francesca Bellucci, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol. 2002 Jan;135(1):266-74.
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Product details
Data download

Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

Hemokinin 1 (human) is an endogenous substance P homolog and acts as a selective agonist at the tachykinin NK1 receptor (IC50 = 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors, respectively). It induces proliferation of B-cells in vitro and exhibits antihypertensive activity in vivo.