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Home / Peptide products / M (76 species) / Magainin / Magainin 2
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Magainin 2
Name
Magainin 2
Molecular structural formula
Purity
≥95%
CAS Number
108433-95-0
Formula
C114H180N30O29S
MW
2466.95
Target
Bacterial; Antibiotic; Fungal
Sequence
Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser
Sequence Shortening
GIGKFLHSAKKFGKAFVGEIMNS
InChIKey
MGIUUAHJVPPFEV-ABXDCCGRSA-N
Solubility in water
50 mg/mL
References
[1]. M Zasloff, et al. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53. [2]. K Matsuzaki, et al. Magainins as paradigm for the mode of action of pore forming polypeptides. Biochim Biophys Acta. 1998 Nov 10;1376(3):391-400.
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Product details
Data download

Magainin 2 assumes an amphiphilic helix when bound to acidic phospholipids, forming a pore composed of a dynamic, peptide-lipid supramolecular complex.