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Home / Peptide products / I (62 species) / Inhibitor / cAMP Dependent PK Inhibitor (5-24)
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cAMP Dependent PK Inhibitor (5-24)
Name
cAMP Dependent PK Inhibitor (5-24)
Molecular structural formula
Purity
≥95%
CAS Number
99534-03-9
Formula
C94H108N32O31
MW
2222.4
Target
PKA
Sequence
Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp
Sequence Shortening
TTYADFIASGRTGRRNAIHD
InChIKey
AXOXZJJMUVSZQY-OCDBTFLZSA-N
Solubility in water
25 mg/mL
References
[1]. Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261(3):989-992. [2]. Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996;377(7-8):513-520.
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Product details
Data download

PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor.