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Home / Peptide products / I (62 species) / Inhibitor / Calcineurin Autoinhibitory Fragment
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Calcineurin Autoinhibitory Fragment
Name
Calcineurin Autoinhibitory Fragment
Molecular structural formula
Purity
≥95%
CAS Number
148067-21-4
Formula
C124H205N39O39S2
MW
2930.38
Target
Phosphatase
Sequence
Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro
Sequence Shortening
ITSFEEAKGLDRINERMPPRRDAMP
Solubility in water
100 mg/mL
References
[1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.
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Product details
Data download

Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death