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Home / Peptide products / E (116 species) / Endomorphin / Big Endothelin-1 (human)
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Big Endothelin-1 (human)
Name
Big Endothelin-1 (human)
Molecular structural formula
Purity
≥95%
CAS Number
121014-53-7
Formula
C189H287N49O55S5
MW
4285.92
Target
Opioid Receptor
Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser|H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-G
Sequence Shortening
CSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRS
References
[1].Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats. T.Katafuchi et al., Brain Res. Mol. Brain Res., 118, 24 (2003) [2].The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes. S.Kaw et al., Proc. Natl. Acad. Sci. USA, 89, 6886 (1992) [3].Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo. T.Kashiwabara et al., FEBS Lett., 247, 73 (1989)
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Product details
Data download

Human Big ET-1 comprises residues 53-90 of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (hET-1), the peptide show less vasoconstrictor activity in vitro, but similar pressor effects in vivo.