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Home / Peptide products / A (265 species) / Apelin / Apelin-12
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Apelin-12
Name
Apelin-12
Molecular structural formula
Purity
≥95%
CAS Number
229961-08-4
Formula
C64H103N21O14S
MW
1422.73
Target
HIV; Apelin Receptor (APJ)
Sequence
Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening
RPRLSHKGPMPF
InChIKey
KIODTAJAFBDDGP-TZIGXLGFSA-N
Solubility in water
≥ 100 mg/mL
References
[1]. Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203. [2]. Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250. [3]. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. [4]. Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78.
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Product details
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Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.