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bis-PEG2-endo-BCN

Name
bis-PEG2-endo-BCN
Molecular structural formula
Purity
≥95%
CAS Number
1476737-97-9
Formula
C28H40N2O6
MW
500.63
Target
ADC Linker
InChIKey
NISHVKOYJUQOBR-UHFFFAOYSA-N
Solubility in DMSO
100 mg/mL
References
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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bis-PEG2-endo-BCN is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). bis-PEG2-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.