Filters
Catalog peptides
Synthesis of unnatural amino acids and other blocks

Z-LVG-CHN2

Name
Z-LVG-CHN2
Molecular structural formula
Purity
99.81%
CAS Number
119670-30-3
Formula
C22H31N5O5
MW
445.51
Target
Cathepsin, HSV, SARS-CoV
Sequence
Z-Leu-Val-Gly-diazomethylketone
Sequence Shortening
Z-LVG-DMK
InChIKey
KRMMQWXJLDORCJ-OALUTQOASA-N
Solubility in DMSO
100 mg/mL
References
[1]. R L Mellgren, et al. Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp Cell Res. 1994 Nov;215(1):164-71. [2]. L Björck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus. J Virol [3]. Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016.
* All products on our website are for scientific research and cannot be used in human body
Product details
Data download

The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication.

Irreversible inhibitor of streptopain.