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Uroguanylin, human

Name
Uroguanylin, human
Molecular structural formula
Purity
≥95%
CAS Number
154525-25-4
Formula
C64H102N18O26S4
MW
1667.89
Target
Guanylate Cyclase
Sequence
Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr- Gly-Cys-Leu(Disulfide bridge: Cys4-Cys12, Cys7-Cys15)
Sequence Shortening
NDDCELCVNVACTGCL (Disulfide bridge: Cys4-Cys12,Cys7-Cys15)
References
[1]. Lewis DK, et al. Hypertrehalosemic hormone in a cockroach: molecular cloning and expression. Mol Cell Endocrinol. 1997;130(1-2):101-108.
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Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effects in an animal model of human colon cancer.