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Teriparatide acetate

Name
Teriparatide acetate
Molecular structural formula
Purity
≥98%
CAS Number
52232-67-4
Formula
C181H291N55O51S2
MW
4117.72
Target
others
Sequence
Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe
Sequence Shortening
SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF
InChIKey
OGBMKVWORPGQRR-UMXFMPSGSA-N
Solubility in water
100 mg/mL
References
[1]. Iwamoto J, et, al. Influence of Teriparatide and Ibandronate on Cortical Bone in New Zealand White Rabbits: A HR-QCT Study. Calcif Tissue Int. 2016
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Teriparatide acetate mediates bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells, and enhancing osteoblast differentiation. By regulating the adenylyl cyclase-cyclic adenosine monophosphate-protein kinase A pathway, it intermittently stimulates the PHT-I receptor on the surface of osteoblasts, bone lining cells and bone marrow stromal stem cells, promotes the differentiation of osteoblasts and prolongs the life span of osteoblasts. The proliferation of osteoblast cell lines was stimulated by the phosphate C-cytoplasmic calcium-protein stimulation Chemicalbook C signaling pathway. By inhibiting the transactivation activity of PPARγ, the differentiation of stromal cells into adipocyte lines was reduced, and the number of osteoblasts was increased. Indirect regulation of bone growth by modulating cytokines, for example, iGF-1 can be induced to bind to osteoblasts, thereby promoting bone formation; The process of bone formation is regulated through the Wnt signaling pathway, thereby increasing bone formation.