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Suc-AAPD-pNA

Name
Suc-AAPD-pNA
Molecular structural formula
Purity
95%
CAS Number
165174-58-3
Formula
C25H32O11N6
MW
592.56
Sequence
Suc-Ala-Ala-Pro-Asp-pNA
Sequence Shortening
Suc-AAPD-pNA
InChIKey
MBLUIJQGADPFTG-USJZOSNVSA-N
References
[1].Propapoptotic effects of NF-kappaB in LNCaP prostate cancer cells lead to serine protease activation. [2]. Cleavage of peptide bonds bearing ionizable amino acids at P(1) by serine proteases with hydrophobic S(1) pocket. [3]. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. [4]. Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity.
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The granzyme B substrate Suc-AAPD-pNA. is also cleaved by ICE.