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Home / Peptide products / Catalog peptides / S (187 species) / Substance P /
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Substance P

Name
Substance P
Molecular structural formula
Purity
≥95%
CAS Number
33507-63-0
Formula
C63H98N18O13S
MW
1347.66
Target
Neurokinin Receptor；Endogenous Metabolite
Sequence
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening
RPKPQQFFGLM-NH2
InChIKey
ADNPLDHMAVUMIW-CUZNLEPHSA-N
Solubility in DMSO
25 mg/mL
Solubility in water
≥ 20 mg/mL
References
[1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.
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Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).