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Somatostatin-28

Name
Somatostatin-28
Molecular structural formula
Purity
≥95%
CAS Number
73032-94-7
Formula
C137H207N41O39S3
MW
3148.6
Target
Somatostatin Receptor
Sequence
Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys(Disulfide bridge Cys17-Cys28)
Sequence Shortening
SANSNPAMAPRERKAGCKNFFWKTFTSC (Disulfide bridge: Cys17-Cys28)
InChIKey
GGYTXJNZMFRSLX-UHFFFAOYSA-N
References
[1]. Martin PA, et al. Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep. J Endocrinol. 1996 Oct;151(1):107-12. [2]. Chisholm C, et al. Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures. Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7.
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Product details
Data download

Somatostatin-28 (sheep, human rat mouse) is a biologically active polypeptide, synthesised in the proximal intestinal epithelial cells. Somatostatin-28 (sheep, human rat mouse) suppresses glucose-stimulated insulin secretion without affecting circulating basal insulin concentration. Somatostatin-28 (sheep, human rat mouse) also targets to somatostatin receptor subtype 5 (SSTR5) to regulate GLP-1 secretion.