RGD (Arg-Gly-Asp) is a 3-amino acid linear peptide that is a cell adhesion sequence that mimics cell adhesion proteins and binds to integrins.
The principle of RGD peptide targeting refers to the binding of three amino acid residues (Arg-Gly-Asp) in the sequence structure of RGD peptide to integrin receptors on the cell surface to achieve targeted therapy of tumor cells.