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Synthesis of unnatural amino acids and other blocks

RGD-4C

Name
RGD-4C
Molecular structural formula
Purity
95%
CAS Number
332179-76-7
Formula
C69H103N19O23S3
MW
1662.86
Target
Integrin
Sequence
Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly(Disulfide Bridge: Cys2-Cys10, Cys4-Cys8)
Sequence Shortening
ACCENLADTYRGPCF
InChIKey
WQLVAVHKXVRFPP-AVWCAVILSA-N
Solubility in DMSO
25 mg/mL
References
[1]. Assa-Munt N, et al. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry. 2001 Feb 27;40(8):2373-8. [2]. Yin R, et al. Effect of RGD-4C position is more important than disulfide bonds on antiangiogenic activity of RGD-4C modified endostatin derived synthetic polypeptide. Bioconjug Chem. 2010 Jul 21;21(7):1142-7. [3]. Zuppone S, et al. A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer. Front Oncol. 2022 Apr 11;12:846958.
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