Pramlintide acetate, as a synthetic analogue of pancreatic amylin, has successfully optimized the peptide molecule by replacing Ala-25, Ser-28 and Ser-29 with proline. This improvement not only improves its solubility and stability, but also maintains its biological activity. Pramlintide acetate can effectively lower postprandial blood sugar levels, slow down the absorption of carbohydrates through synergistic effects with insulin, inhibiting the secretion of glucagon and slowing down the gastric emptying rate, showing a significant anti-hyperglycemic effect.