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Synthesis of unnatural amino acids and other blocks

Polistes Mastoparan

Name
Polistes Mastoparan
Molecular structural formula
Purity
≥95%
CAS Number
74129-19-4
Formula
C77H127N21O18
MW
1635
Target
Bacterial
Sequence
Val-Asp-Trp-Lys-Lys-Ile-Gly-Gln-His-Ile-Leu-Ser-Val-Leu-NH2
Sequence Shortening
VDWKKIGQHILSVL-NH2
InChIKey
XKUYSBUJKLFGFG-XVGFDQGISA-N
References
[1]. Nakao S, et al. Comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells. Biochim Biophys Acta. 2011 Jan;1808(1):490-7.
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Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K+ efflux and inhibits cell viability with EC50 of 5 μM.