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Synthesis of unnatural amino acids and other blocks

PUMA BH3

Name
PUMA BH3
Molecular structural formula
Purity
95%
Formula
C128H202N42O43S1
MW
3049.29
Target
Bcl-2 Family
Sequence
Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg
Sequence Shortening
EEQWAREIGAQLRRMADDLNAQYER
Solubility in DMSO
100 mg/mL
References
[1]. Evaluation of the BH3-only protein Puma as a direct Bak activator.
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Product details
Data download

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.