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Synthesis of unnatural amino acids and other blocks

PT-141

Name
PT-141
Molecular structural formula
Purity
≥95%
CAS Number
189691-06-3
Formula
C50H68N14O10
MW
1025.2
Target
Melanocortin Receptor
Sequence
Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys -Asp-Lys
Sequence Shortening
Ac-{Nie-Asp}-His-{D-Phe}-RWKDK
InChIKey
FFHBJDQSGDNCIV-MFVUMRCOSA-N
References
[1]. Pfaus J, et al. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007 Nov;4 Suppl 4:269-79. [2]. Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102.
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Product details
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Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders.