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Synthesis of unnatural amino acids and other blocks

PMAP-23

Name
PMAP-23
Molecular structural formula
Purity
95%
Formula
C140H229N43O28
MW
2962.59
Sequence
Arg-Ile-Ile-Asp-Leu-Leu-Trp-Arg-Val-Arg-Arg-Pro-Gln-Lys-Pro-Lys-Phe-Val-Thr-Val-Trp-Val-Arg
Sequence Shortening
Arg-Ile-Ile-Asp-Leu-Leu-Trp-Arg-Val-Arg-Arg-Pro-Gln-Lys-Pro-Lys-Phe-Val-Thr-Val-Trp-Val-Arg
References
[1].M. Zanetti, P. Storici, A. Tossi, M. Scocchi, R. Gennaro, J. Biol. Chem. 269 (1994) 7855–7858. Guerreiro, Catarina IPD, et al. Protein expression and purification 59.1 (2008): 161-168.
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Product details
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This highly cationic peptide was derived from porcine myeloid cells, and forms a typical amphipathic structure compared to other antibacterial peptides.  PMAP-23 shows antibacterial activity against Gram positive and negative strains but no human erythrocyte lysis activity.