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Synthesis of unnatural amino acids and other blocks

Octreotide acetate

Name
Octreotide acetate
Molecular structural formula
CAS Number
79517-01-4
Formula
C51H70N10O12S2
MW
1079.29
Sequence Shortening
fCFwKTCT-ol(Disulfide bridge: Cys2-Cys7)
Sequence
D-Phe-Cys(1)-Phe-D-Trp-Lys-Thr-Cys(1)-Thr-ol(Disulfide bridge: Cys2-Cys7)
InChIKey
DEQANNDTNATYII-OULOTJBUSA-N
DMSO solubility
250 mg/mL
Solubility in water
25 mg/mL
Purity
≥98%
References
[1]. Wang M, et al. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56. [2]. Kim S, et al. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. J Am Anim Hosp Assoc. 2015 Nov-Dec;51(6):407-12.
Target
Somatostatin Receptor
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Product details
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Octreotide acetate is a synthetic, long-acting somatostatin analog that effectively controls symptoms by inhibiting the secretion of growth hormone, glucagon, and insulin, reducing the levels of these hormones. In addition, the drug can inhibit the response of luteinizing hormone (LH) to gonadotropin-releasing hormone (GnRH), reduce visceral blood flow, and inhibit the secretion of serotonin (5-HT), gastrin, etc.