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Nonapeptide-1

Name
Nonapeptide-1
Molecular structural formula
Synonym
Melanostatine-5
Purity
≥95%
CAS Number
158563-45-2
Formula
C61H87N15O9S
MW
1206.62
Target
Melanocortin Receptor
Sequence
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
Sequence Shortening
MPfRwFKPV-NH2
InChIKey
KNFLNGRLKALWRF-LDXSYGEZSA-N
Solubility in water
44.44 mg/mL
References
[1]. Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269(47):29846-54. [2]. Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31(6), 565-571 (1997). [3]. Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39(2):327-335.
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Nonapeptide-1 is an active peptide with skin-lightening effects. It can bind to the MC1 receptor on melanocytes and effectively inhibit the production of melanin. In addition, it can block the activation process of tyrosinase, reduce skin pigmentation and dark spots, and make the skin tone more even.


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