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Myosin Kinase Inhibiting Peptide

Name
Myosin Kinase Inhibiting Peptide
Molecular structural formula
Purity
≥95%
CAS Number
224579-74-2
Formula
C40H78N18O11
MW
987.2
Target
Myosin; CaMK; Autophagy
Sequence
Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2
Sequence Shortening
RKKYKYRRK-NH2
InChIKey
JPOKAKNGULMYHZ-UILVTTEASA-N
Solubility in water
100 mg/mL
References
[1]. Lukas TJ, et al. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J Med Chem. 1999 Mar 11;42(5):910-9.
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Product details
Data download

MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.