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Melanotan II, MT-Ⅱ

Name
Melanotan II, MT-Ⅱ
Molecular structural formula
Purity
≥95%
CAS Number
121062-08-6
Formula
C50H69N15O9
MW
1024.2
Target
others
Sequence
Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2(Lactam bridge:Asp2-Lys7)
Sequence Shortening
Ac-{Nle}-DH-{D-Phe}-RWK-NH2(Lactam bridge :Asp2-Lys7)
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N
Solubility in water
6.67 mg/mL
References
[1]. Breindahl T, et al. Identification and characterization by LC-UV-MS/MS of melanotan II skin-tanning products sold illegally on the Internet. Drug Test Anal. 2015 Feb;7(2):164-72. [2]. Giuliano F, et al. Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. Neuroscience. 2006;138(1):293-301. [3]. Ter Laak MP, et al. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur J Pharmacol. 2003 Feb 21;462(1-3):179-83. [4]. Wessells H, et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9. [5]. De Jonghe BC, et al. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51.
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Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning.