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Melanin Concentrating Hormone, human, mouse, rat MCH, human, mouse, rat

Name
Melanin Concentrating Hormone, human, mouse, rat MCH, human, mouse, rat
Molecular structural formula
Purity
≥95%
CAS Number
128315-56-0
Formula
C105H160N30O26S4
MW
2386.8
Target
MCHR1 (GPR24)
Sequence
Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val(Disulfide bridge:Cys7-Cys16)
Sequence Shortening
DFDMLRCMLGRVYRPCWQV (Disulfide bridge:Cys7-Cys16)
InChIKey
MWLPXSMFEPHETN-QRXCLJFASA-N
References
[1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9.
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Product details
Data download

MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively.