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Mca-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)

Name
Mca-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)
Molecular structural formula
Purity
95%
CAS Number
1802078-33-6
Formula
C87H129O28N27S1
MW
2033.18
Target
others
Sequence
MCA-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2
Sequence Shortening
Mca-SEVKMDAEFR-K(Dnp)-RR-NH2
InChIKey
RZXQCNCGGHGNLH-DJTRRQCOSA-N
References
[1].Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein .
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Product details
Data download

This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.