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Mc-Val-Cit-PABC-PNP

Name
Mc-Val-Cit-PABC-PNP
Molecular structural formula
Purity
≥95%
CAS Number
159857-81-5
Formula
C35H43N7O11
MW
737.76
Target
ADC Linker
InChIKey
HYSPJPGXSALJRR-DHIFEGFHSA-N
Solubility in DMSO
≥ 37 mg/mL
References
[1]. Li Y, et al. Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575. [2]. Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.
* All products on our website are for scientific research and cannot be used in human body
Product details
Data download

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs.