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Synthesis of unnatural amino acids and other blocks

Lys(MMT)-PAB(OH)-NH-oxydiAc-NH-PEG8-N3

Name
Lys(MMT)-PAB(OH)-NH-oxydiAc-NH-PEG8-N3
Molecular structural formula
Purity
≥95%
CAS Number
1224601-12-0
Formula
C55H77N7O14
MW
1060.24
Target
ADC Linker
InChIKey
PKUIBTBLKQVEJS-XHIZWQFQSA-N
References
[1]. Serengulam V. Govindan, et al. EFFICACY OF ANTI-HLA-DR ANTIBODY DRUG CONJUGATE IMMU-140 (hL243-CL2A-SN-38) IN HLA-DR POSITIVE CANCERS. Patent US20170360770.
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Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a cleavable antibody agent conjugate linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.